These seven projects connect important research questions with named NHRTI investigators and collaborators. They form part of the institute’s research portfolio; contact the team for study-specific information.
A closer look at the questions.
From mosquito control to child health and nutrition, each project begins with a question that needs evidence.
Explore a plain-language summary, meet the investigators and open the study details for the scientific description.
Browse all seven projectsSeven projects. Different paths to understanding.
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Malaria · Vector control
Evaluating a new indoor residual spray
How well can an indoor spray control mosquitoes that resist insecticides?
Principal Investigator: Mbanga Muleba
Study details
Small community trials in Zambia evaluate a new Syngenta indoor residual spray against resistant, field-collected Anopheles funestus and Anopheles gambiae, alongside susceptible insectary-reared Anopheles gambiae of the KISUMU strain. The project contributes evidence on vector control tools in settings affected by insecticide resistance.
Nutrition · Laboratory methods
Improving the measurement of vitamin A status
How can we measure the body’s vitamin A stores more accurately?
Principal Investigator: Justin Chileshe
Study details
The project develops a “Wonder Woman” kinetic model and evaluates liver reserve cut-offs for vitamin A status. It is part of NHRTI’s work to refine the measurement of vitamin A stores and improve the evidence used to assess micronutrient deficiency.
Malaria · Maternal health
Malaria screening and prevention in pregnancy
How can the first antenatal visit support malaria prevention and treatment?
Principal Investigator: Dr. Jean-Bertin Bukasa Kabuya · Co-Investigator: Dr. Christine Manyando
Study details
This study examines the safety and efficacy of intermittent presumptive treatment in pregnancy with sulfadoxine-pyrimethamine using rapid diagnostic test screening and treatment at the first antenatal care visit. The research asks how approaches at the first visit can support malaria prevention and treatment during pregnancy.
Malaria · Clinical and translational science
Understanding severe malaria
What happens inside the body when malaria becomes severe?
Principal Investigator: Dr. J. B. Kabuya · Co-Investigator: Dr. Michael Nambozi
Study details
Clinical and translational investigations examine the biological processes behind severe malaria. This work connects clinical observations with laboratory investigation to better understand why the disease takes different forms and how serious outcomes develop.
Malaria · Access to treatment
Severe malaria treatment in remote settings
What treatment approaches can be studied where onward referral is difficult?
Investigators: Dr. C. Manyando, Dr. M. Nambozi and Dr. S. Hachizovu
Study details
The project studies severe malaria treatment with rectal artesunate and artemisinin-based combination therapy in remote settings. It examines a difficult service-delivery question: how treatment approaches can be studied where onward referral is constrained. The project description is research information, not instructions for self-treatment.
Implementation science · Adolescent health
Connecting HIV services and cervical cancer prevention
Can established HIV services help adolescent girls access HPV vaccination?
Study team: Sam Miti, Jean M. Hunleth, Gershom Chongwe, Aliness Dombola and Michelle Silver
Study details
This study investigates how HIV service infrastructure can support HPV vaccination for adolescent girls in Zambia. By studying integration within adolescent HIV clinics, it explores how established services can provide another important prevention intervention to people already using them.
Malaria · Multisite clinical research
SMAART-MAP: a platform for severe malaria research
Which approaches may improve outcomes for children with severe malaria?
Principal Investigator: Dr. Mike Chaponda
Study details
The Severe Malaria A Research and Trials consortium — Multisite Adaptive Platform trial studies approaches to improving outcomes for children with severe malaria. Work at St Paul’s Hospital in Nchelenge District is undertaken in collaboration with Imperial College London, with a focus on severe anaemia and kidney dysfunction.
Questions move between teams.
Field studies, laboratory investigations and clinical research draw on complementary expertise. The investigator named on each project can help direct a study-specific enquiry.
These descriptions provide research information; they do not advertise recruitment or provide treatment instructions.
Contact the research team